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  • Common uses
  • How to take the medication
  • Common side effects
  • Precautions & interactions

How Belantamab Mafodotin-blmf Injection works, side effects, interactions and precautions.

Belantamab Mafodotin-blmf Injection

Belantamab Mafodotin-blmf Injection

(bel an' ta mab) (ma" foe doe' tin)

Brand Name(s): , Blenrep®


Belantamab mafodotin-blmf injection may cause serious eye or vision problems, including vision loss. Tell your doctor if you have or have a history of vision or eye problems. If you experience any of the following symptoms, call your doctor immediately: blurred vision, vision changes or loss, or dry eyes.

Because of the risk of vision problems with this medication, belantamab mafodotin-blmf is only available through a special program called Blenrep REMS®. You, your doctor, and your healthcare facility must be enrolled in this program before you can receive belantamab mafodotin-blmf. Ask your doctor for more information about this program.

Do not wear contact lenses during treatment unless directed by a doctor or eye doctor. Use a preservative-free lubricant eye drop as directed by your doctor during your treatment.

Do not drive a car or operate machinery until you know how this medication affects your vision.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment. Your doctor will order an eye exam before and several times during your treatment, especially if you notice a change in vision.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with belantamab mafodotin-blmf and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ([WEB]) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of receiving belantamab mafodotin-blmf.

WHY is this medicine prescribed?

Belantamab mafodotin-blmf injection is used to treat multiple myeloma (a type of cancer of the bone marrow) that has returned or has not improved in adults who have received at least 4 other medications. Belantamab mafodotin-blmf is in a class of medications called antibody-drug conjugates. It works by killing cancer cells.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Belantamab mafodotin-blmf comes as a powder to be mixed with liquid and injected intravenously (into a vein) over 30 minutes by a doctor or nurse in a hospital or medical facility. It is usually given once every 3 weeks. The cycle may be repeated as recommended by your doctor. The length of your treatment depends on how well your body responds to the medication and any side effects that you experience.

A doctor or nurse will watch you closely while you are receiving the medication to be sure you are not having a serious reaction to the medication. Tell your doctor or nurse immediately if you experience any of the following symptoms: chills; flushing; itching or rash; shortness of breath, cough, or wheezing; tiredness; fever; dizziness or lightheadedness; or swelling of your lips, tongue, throat, or face.

Your doctor may reduce your dose or temporarily or permanently stop your treatment. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with belantamab mafodotin-blmf.

What SPECIAL PRECAUTIONS should I follow?

Before receiving belantamab mafodotin-blmf injection,

  • tell your doctor and pharmacist if you are allergic to belantamab mafodotin-blmf, any other medications, or any of the ingredients in belantamab mafodotin-blmf injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had bleeding problems.
  • tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You should not start receiving belantamab mafodotin-blmf injection until a pregnancy test has shown that you are not pregnant. If you are a woman who is able to become pregnant, you must use effective birth control during your treatment and for 4 months after your final dose. If you are male with a female partner who could become pregnant, you must use effective birth control during your treatment and for 6 months after your final dose. Talk to your doctor about methods of birth control that will work for you. If you or your partner become pregnant while receiving belantamab mafodotin-blmf injection, call your doctor. Belantamab mafodotin-blmf injection may harm the fetus.
  • tell your doctor if you are breastfeeding. Do not breastfeed during your treatment and for 3 months after your final dose.
  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of receiving belantamab mafodotin-blmf injection.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

If you miss an appointment to receive a dose of belantamab mafodotin-blmf, call your doctor right away.

What SIDE EFFECTS can this medicine cause?

Belantamab mafodotin-blmf may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • constipation
  • diarrhea
  • loss of appetite
  • joint or back pain
  • tiredness

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • unusual bleeding or bruising
  • shortness of breath, chest pain, cough

Belantamab mafodotin-blmf may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ([WEB]) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at [WEB]. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Ask your pharmacist any questions you have about belantamab mafodotin-blmf.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS® Patient Medication Information™. © Copyright, 2023. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: July 15, 2022.

Belantamab Mafodotin-blmf Injection is commonly used to treat:

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