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Stomach Cancer Treatment Options by Stage

For information about the treatments listed below, see the Treatment Option Overview section.

Stage 0 (Carcinoma in Situ)

Treatment of stage 0 may include the following:

  • Surgery (total or subtotal gastrectomy).
  • Endoscopic mucosal resection.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Stage I Gastric Cancer

Treatment of stage I gastric cancer may include the following:

  • Surgery (total or subtotal gastrectomy).
  • Endoscopic mucosal resection for certain patients with stage IA gastric cancer.
  • Surgery (total or subtotal gastrectomy) followed by chemoradiation therapy.
  • A clinical trial of chemoradiation therapy given before surgery.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Stages II and III Gastric Cancer

Treatment of stage II gastric cancer and stage III gastric cancer may include the following:

  • Surgery (total or subtotal gastrectomy).
  • Chemotherapy given before surgery.
  • Surgery (total or subtotal gastrectomy) followed by chemoradiation therapy or chemotherapy.
  • A clinical trial of chemoradiation therapy given before surgery.
  • A clinical trial of chemotherapy given before surgery.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Stage IV Gastric Cancer, Gastric Cancer That Cannot Be Removed By Surgery, and Recurrent Gastric Cancer

Treatment of stage IV gastric cancer, gastric cancer that cannot be removed by surgery, or recurrent gastric cancer may include the following:

  • Chemotherapy as palliative therapy to relieve symptoms and improve the quality of life.
  • Targeted therapy with a monoclonal antibody with or without chemotherapy.
  • Immunotherapy.
  • Endoluminal laser therapy or endoluminal stent placement to relieve a blockage in the stomach, or gastrojejunostomy to bypass the blockage.
  • Radiation therapy as palliative therapy to stop bleeding, relieve pain, or shrink a tumor that is blocking the stomach.
  • Surgery as palliative therapy to stop bleeding or shrink a tumor that is blocking the stomach.
  • A clinical trial of new combinations of chemotherapy as palliative therapy to relieve symptoms and improve the quality of life.
  • A clinical trial of targeted therapy with a multikinase inhibitor.
  • A clinical trial of surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

This information is not intended to replace the advice of a doctor. Navigating Care disclaims any liability for the decisions you make based on this information. This information was sourced and adapted from Adapted from the National Cancer Institute's Physician Data Query (PDQ®) Cancer Information Summaries on www.cancer.gov.

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