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Regimen Information

For VMP, including Side Effects


Drugs in this Regimen:

For the treatment of Multiple Myeloma

How VMP chemotherapy is given and possible side effects.

VMP for the treatment of Multiple Myeloma

VMP is an acronmyn for a treatment regimen used for multiple myeloma.


V = Velcade (bortezomib)

M = melphalan

P = prednisone


  • Risk of Infection

  • Nausea & Vomiting

  • Bleeding

  • Neuropathy

For more information, see the 'Expert Resources' tab below.

Community Responses

Often, the most helpful information regarding treatment side effects comes not from clinical brochures, but rather from other patients like you. We've collected the most helpful community resources to help you prepare for the side effects and coping tips for your chemotherapy regimen.

What side effects did you experience while on this medication?

Hi, I'm Maggie

Continuation to my previous post. Nothing took away those side effects. I took Tylenol for fever. I can only take Tylenol because I have a kidney transplant. Nothing stopped the vomiting but I drank Gatorade to help with dehydration.

  • Mon Mar 17, 2014
Hi, I'm Maggie

I was diagnosed in March 2011. I began with Melphalan tablets. The first few days , I developed low grade fevers. The oncologist asked me to stop. He then put me on IV Velcade and Dexamethasone. This worked brought the serum kappa down from (5000’s) to normal within a couple of months. The only side effects at the time were fever, vomiting and diarrhea. I would of course be very weak from that and not eating. It took a couple of months for this to subside. Now I just get nauseous and rarely vomit. I also continue to get low grade fevers. At times my fevers go as high as 103 – 104. When this happens, I cannot get out of bed let alone take care if any household chores or cooking. I am a 48 year old single mother of 3 boys. 29, 25, and 14. My granddaughter will be 5 I. June. They help with what they can. My granddaughter and 14 year old care for me the best. :)

  • Mon Mar 17, 2014

This discussion needs your voice!

What were the specific side effects that you experienced while taking this medication? How did you manage them?

What coping tips would you give to new patients on this regimen?

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This discussion needs your voice!

What do you wish you had known before taking this medication? What information would you like to pass on to patients who are beginning this medication?

Treatment Overview

This chemotherapy regimen is commonly used to treat:

Other chemotherapy regimens for the treatment of Multiple Myeloma:

See Expert Resources

The Navigating Care Library includes articles about cancer, chemotherapy regimens and drugs from the the National Cancer Institute and other experts.