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Regimen Information

For Nexavar, including Side Effects


Drugs in this Regimen:

For the treatment of Liver Cancer

How Nexavar chemotherapy is given and possible side effects.

Nexavar for the treatment of Liver Cancer

Nexavar (Sorafenib) is a drug used in the treatment of liver cancer.


  • Nausea & Vomiting

  • Diarrhea

  • Hand Foot Syndrome

  • Hair Loss

For more information, see the 'Expert Resources' tab below.

Community Responses

Often, the most helpful information regarding treatment side effects comes not from clinical brochures, but rather from other patients like you. We've collected the most helpful community resources to help you prepare for the side effects and coping tips for your chemotherapy regimen.

What side effects did you experience while on this medication?

Hi, I'm kathy

Nexavar for treatment of primary HCC This drug is a bear. It caused me to have a rash within the first week of taking it. Head to toe. Was given doxycyline to help control it. The biggest problem with nexavar is the skin reactions( hand /foot syndrome) You need lots and lots of good lotion. The Nexavar hotline is great help as well. They had me bathe in dandruff shampoo to help control the rash. The next big thing is the mouth sores. You can maybe get your onc. to prescibe you some magic mouthwash but it is pretty nasty almost as bad as the mouth sores. I have tried salt water gargles as well as flat club soda. That works ok but isnt very plesant either. Best bet keep welll hydarated and suck on hard candy if you can. Fatigue, diarrhea and hair loss seem to be part of any chemo treatment so nothing really new to add to this. I found that finding a good place for a pedicure helps with the calluses. Make sure you tell them you are chemo so they dont “dig” to deep you wont heal. I think that it is very hard to say on the max dose of the drug which is 2 2 x a day or 800 mg total. So dont get discouraged if your onc. changes your dosing around ALOT Hope this is helpful to someone

  • Thu Nov 8, 2012

This discussion needs your voice!

What were the specific side effects that you experienced while taking this medication? How did you manage them?

What coping tips would you give to new patients on this regimen?

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What do you wish you had known before taking this medication? What information would you like to pass on to patients who are beginning this medication?

Treatment Overview

This chemotherapy regimen is commonly used to treat:

Other chemotherapy regimens for the treatment of Liver Cancer:

See Expert Resources

The Navigating Care Library includes articles about cancer, chemotherapy regimens and drugs from the the National Cancer Institute and other experts.